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Old 03-06-2003, 08:18 AM   #1
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Default Advanced Optics

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One prospect for this technique is determining exactly how cell membranes work, opening the door to designer medicines that could kill harmful cells or repair damaged ones.
Is this saying scientists will be able to actually see the cell work?
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Old 03-06-2003, 01:05 PM   #2
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Is this saying scientists will be able to actually see the cell work?
Well, not with this technique, or at least not for a long time.

You have to get the gold whisker quite close to the object you're trying to image, which I am guessing is why they say it will work on cell membranes (but not mentioning inner workings of the cell).

I could envision the technique being expanded to use inside a cell, though, by using Raman scattering off of a tiny gold-coated microsphere, which is moved to the area in question using laser tweezers.

It is a rather impressive demonstration of how to extend the range of optical techniques. Using visible light, you can't image anything much smaller than a micron, and they're getting details that are 1/40 that size, and their goal is to get to 1/200 of a micron. Not only do they get physical structure information, they get Raman spectral information, which tells you something about the molecular bonds.

Very cool laser stuff indeed!

-Kelly
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