monkenstick

vanderzyden, the following evidence I feel amply demonstrates the common ancestry (and not "common design") of chimpanzees and human beings:

Human Urate Oxidase Psuedogene CDS (exons 1-8)

atggcccact accataacaa ctataaaaaga atgatgagg tggagtttgt ccgaactggc tatgggaagg aaatggtaaa agttctccat attcagtgag atggaaaata tcacagcatt aaagaggtgg caacttcagt gcaacttact ctaagttcca aaaaagatta cctgcatgga gataattcag acatcatccc tacagacacc atcaagaaca cagttcatgt cttggcaaag tttaaagaa atcaaaagca tagaagcctt tggtgtgaat atttgtgagc attttctttc ttcttttaac catgtaatcc gagctcaagt ctacatggaa gaaatccctt ggaagcatct tggaaag aatggagtta agcatgtcca tgcatttatt cacactccca ctggaacaca cttctgtgaa gttgaacagc tgagaagt ggaccccaag tcattcattc tggaatcaaa gacctcaagg tcttgaaaac aacacagtct ggatttgaag gtttcatcaa ggaccagttc actaccctcc ctgaggtgaa ggactgatgc tttgccaccc aagtgtactg caagtggcgc taccaccagt gcagggatgt ggacttcaag gctacctgg gacaccattc gggaccttgt catggagaaa tctgctgggc cctatgacaa aggtgaatac ttgacctctg tgcagaagac cctctgtgat atccaggtgc tctccctgag ccgagttcct gcg atagaagata tggaaatcag cctgccaaac attcactact tcaacataga catgtccaaa atgggtctga tcaacaagga agaggtcttgctgc cattagacaa tccatatgga aaaattactg gtacagtcaa gaggaagttg
tcttcaagac tgtga

Chimpanzee Urate Oxidase Psuedogene (exons 1-8)

atggcccact accataacaa ctataaaaag aatgatgagg tggagtttgt ccgaactggc tatgggaagg atatggtaaa agttctccat attcagtgag atggaaaata tcacagcatt aaagaggtgg caacttcagt gcaacttact ctaagttcca aaaaagatta cctgcatgga gataattcag acatcatccc tacagacacc atcaagaaca cagttcatgt cttggcaaag tttaaagaa atcaaaagca tagaagcctt tggtgtgaat atttgtgagc attttctttc ttcttttaac catgtaatcc gagctcaagt ctatgtggaa gaaatccctt ggaagcatct tgaaaag aatggagtta agcatgtcca tgcatttatt cacactccca ctggaacaca cttcggtgaa gttgaacagc tgagaagt ggaccccaag tcattcattc tggaatcaaa gacctcaagc tcttgaaaac aacacagtct ggatttgaag gtttcatcaa ggaccagttc actaccctcc ctgaggtgaa ggactgatgc tttgccaccc aagtgtactg caagtgacgc taccaccagt gcagggatgt ggacttcaag gctacctgg gacaccattc gggaccttgt catggagaaa tctgctgggc cctatgacaa agatgaatac tcgccctctg tgcagaagac cctctgtgat atccaggtgc tctccctgag ccgagttcct gcg atagaagata tggaaatcag cctgccaaac attcactact tcaacataga catgtccaaa atgggtctga tcaacaagga agag gtcttgctgc cattagacaa tccatatgga aaaattactg gtacagtcaa gaggaagttg tcttcaagac tgtga

BLAST Pairwise Alignment of the two sequences above;

Score = 1702 bits (885), Expect = 0.0
Identities = 905/915 (98%)
Strand = Plus / Plus

Human Urate Oxidase Pseudogene translated:

Met A H Y H N N Y K K N D E V E F V R T G Y G K E Met V K V L H I Q Stop D G K Y H S I K E V A T S V Q L T L S S K K D Y L H G D N S D I I P T D T I K N T V H V L A K F K E I K S I E A F G V N I C E H F L S S F N H V I R A Q V Y Met E E I P W K H L G K N G V K H V H A F I H T P T G T H F C E V E Q L R S G P Q V I H S G I K D L K V L K T T Q S G F E G F I K D Q F T T L P E V K D Stop C F A T Q V Y C K W R Y H Q C R D V D F K A T W D T I R D L V Met E K S A G P Y D K G E Y L T S V Q K T L C D I Q V L S L S R V P A I E D Met E I S L P N I H Y F N I D Met S K Met G L I N K E E V L L P L D N P Y G K I T G T V K R K L S S R L Stop

Chimpanzee Urate Oxidase Psuedogene translated:

Met A H Y H N N Y K K N D E V E F V R T G Y G K D Met V K V L H I Q Stop D G K Y H S I K E V A T S V Q L T L S S K K D Y L H G D N S D I I P T D T I K N T V H V L A K F K E I K S I E A F G V N I C E H F L S S F N H V I R A Q V Y V E E I P W K H L E K N G V K H V H A F I H T P T G T H F G E V E Q L R S G P Q V I H S G I K D L K L L K T T Q S G F E G F I K D Q F T T L P E V K D Stop C F A T Q V Y C K Stop R Y H Q C R D V D F K A T W D T I R D L V Met E K S A G P Y D K D E Y S P S V Q K T L C D I Q V L S L S R V P A I E D Met E I S L P N I H Y F N I D Met S K Met G L I N K E E V L L P L D N P Y G K I T G T V K R K L S S R L Stop


The above sequences are from humans and chimps. They are 98 percent homologous - 905 out of 915 nucleotides in the coding regions of these genes is shared.

What is also shared is "premature stop codons"
- A stop codon that appears in the middle of a gene, rather than at the end. What this effectively does is truncate the protein - it is no longer translated to the end.

i.e. instead of getting
Met A H Y H N N Y K K N D E V E F V R T G Y G K E Met V K V L H I Q Stop D G K Y H S I K E V A T S V Q L T L S S K K D Y L H G D N S D I I P T D T I K N T V H V L A K F K E I K S I E A F G V N I C E H F L S S F N H V I R A Q V Y Met E E I P W K H L G K N G V K H V H A F I H T P T G T H F C E V E Q L R S G P Q V I H S G I K D L K V L K T T Q S G F E G F I K D Q F T T L P E V K D Stop C F A T Q V Y C K W R Y H Q C R D V D F K A T W D T I R D L V Met E K S A G P Y D K G E Y L T S V Q K T L C D I Q V L S L S R V P A I E D Met E I S L P N I H Y F N I D Met S K Met G L I N K E E V L L P L D N P Y G K I T G T V K R K L S S R L Stop

what you get instead is;

Met A H Y H N N Y K K N D E V E F V R T G Y G K E Met V K V L H I Q Stop

this renders the gene non-functional. It is severely truncated, it is missing its C-terminal signal peptide which targets it to the correct place in the cell. Its also missing about 90 percent of the original protein.

A fully functional copy of urate oxidase

Aotus trivirgatus (owl monkey) urate oxidase gene:

atggcccact accataacga ctataaaaag aacgatgagg tggagtttgt acgaactggc tatgggaagg atatggtaaa agtcctccat attcagcgag atggaaaata tcacagcatt aaagaggtgg caacttcagt gcaacttact ctgagttcca aaaaagatta cctgcatgga gacaattcag atatcatccc tacagacacc atcaagaaca cagttcatgc cttggcaaag tttaaagga atcaaaagca tagaagcctt tgctgtgaat atttgtcagc attttctttc ttcttttaac catgtcatcc gaactcaagt ctatgtggaa gaaatccctt ggaagcggct tgaaaag aatggagtta agcatgtcca tgcatttatt cacactccca ctggaacaca cttctgtga gttgaacagc tgagaagt ggacccccag ttattcattc tggaatcaaa gacctcaagg tcttgaaaac aacccagtct ggatttgaag gtttcatcaa ggaccagttc accaccctcc ctgaggtgaa ggaccgatgc tttgccgcac aagtatactg caagtggcgc taccaccagt gcagggatgt ggacttcgag gctacctgg gacaccattc gggacgttgt cctagagaaa tttgctgggc cctatgacaa aggcgagtac tcgccgtctg tgcagaagac cctctatgat atccaggtgg tctccctgag tcaagtccct gagatagacgata tggaaatcag cctgccaaac attcactact tcaacataga catgtccaaa atgggtctga tcaacaagga agaggtcttgctgc cattagacaa tccatatggc aaaattactg gtacagtcaa gaggaagttg tcttcgagac tgtga

Translation:

Met A H Y H N D Y K K N D E V E F V R T G Y G K D Met V K V L H I Q R D G K Y H S I K E V A T S V Q L T L S S K K D Y L H G D N S D I I P T D T I K N T V H A L A K F K G I K S I E A F A V N I C Q H F L S S F N H V I R T Q V Y V E E I P W K R L E K N G V K H V H A F I H T P T G T H F C E V E Q L R S G P P V I H S G I K D L K V L K T T Q S G F E G F I K D Q F T T L P E V K D R C F A A Q V Y C K W R Y H Q C R D V D F E A T W D T I R D V V L E K F A G P Y D K G E Y S P S V Q K T L Y D I Q V V S L S Q V P E I D D Met E I S L P N I H Y F N I D Met S K Met G L I N K E E V L L P L D N P Y G K I T G T V K R K L S S R L Stop

Blast pairwise alignments:

human/owl monkey:

Score = 1483 bits (771), Expect = 0.0
Identities = 867/915 (94%)
Strand = Plus / Plus

chimp/owl monkey

Score = 1494 bits (777), Expect = 0.0
Identities = 869/915 (94%)
Strand = Plus / Plus

As you can no doubt see, this functional copy has only one stop codon, at the end of the protein. It is also 94 percent homologous to the pseudogenes in humans and chimps.

some additional information:

Function of urate oxidase:

<a href="http://www.biochem.missouri.edu/ptipton_urate.html" target="_blank">http://www.biochem.missouri.edu/ptipton_urate.html</a>

Nonsense mediated Decay:

<a href="http://www.ncbi.nlm.nih.gov/Coffeebreak/CB7_NMD/page.html" target="_blank">http://www.ncbi.nlm.nih.gov/Coffeebreak/CB7_NMD/page.html</a>


So, what we have is homologous DNA in humans and chimps which has no function. The "Common Creator" hypothesis implies that similar DNA is due to similar function.

no function - no C______ C________

therefore C_______ A________

you can fill in the blanks vanderzyden

Doubting Didymus

no function - no Common Creator

therefore Cleverly Avoid?

Doubting Didymus

More likely: Cause Aggrevation.

monkenstick

lol, most probably

Valentine Pontifex

I think we have a typo here.

Valentine Pontifex

I would be careful about that reasoning. It is possible that a common creator could put in the same functionless feature. Human designers are certainly not beyond that.

What monkenstick has done if far more profound than simply showing that humans and chimps have the noncoding sequences in common. After all the evolution deniers can argue 1) non-functional sequences might have a function and 2) a common densigner can put in common features that are not what we humans would call functional.

How we get around this it by pointing out that these are not merely non-function, they are clear errors. Having very specific errors in clear evidence that copying has occured.
That this similarities of human and chimp genomes is due to copying is a fundamental expectation of evolution.

See: <a href="http://www.talkorigins.org/faqs/molgen/" target="_blank">Plagiarized Errors and Molecular Genetics</a>

Dr S

So not only are we just a bunch of chimps...we're a screwed up bunch of chimps.

That really explains a lot; if you think about it.

monkenstick

yes, you're right valentine, it is a bit of a typo - It just illustrates simply what a stop codon actually does, in case vanderzyden (or others) didn't know.

pangloss

Don't you folks get it?

Good design is evidence FOR a creator.

Then, so is bad design.

Because, afterall, who can know the mind of the creator?

Albion

Yes, or this is only to be expected because of the degeneration that occurred after the Fall. No doubt Adam's DNA, when first created, didn't contain all that extra stuff.