Freethought & Rationalism Archive

rafe gutman · 12-14-2002, 03:51 PM

Quote:

by lpetrich:
And while it has an innate immune system, like most of the rest of the animal kingdom, it does not [have] a trace of the jawed-vertebrate adaptive immune system.

not so fast buddy! just last month someone reported the discovery of a family of<a href="http://www.nature.com/cgi-taf/DynaPage.taf?file=/ni/journal/v3/n12/full/ni849_fs.html" target="_blank">proto-immunoglobulin</a> genes in amphioxus. they're called VCBP1 thru 5 (variable-region containing chitin binding protein). here's the amino acid <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=protein&list_uids=24528 454&dopt=GenPept" target="_blank">sequence</a> of one of them:

MKFVLGLVLLAVGAHAMTIVTVSTPEPKVEASVGGSAELKCEFDIQPNST QPPTIAWFKGNDDFRGVERI
YTGHKVWGNETERREDSFGDYIGRVEVADLDKPAIKISGIKSTDFARYWC TVAEWGVRTELGVDAKSVLL
TETGHSEASIDISVSGEKDVEEGGDVEMTCRCHGCTSAAIFDWFKGAFAG SEWVTTGNYTHIAAKVDVGV
LGFPNPIEIDDGFGQFSVTPSNSLRLTGAQVADAGRYWCKVTSGGSVDIK ATVLKVKVPEFTCAGKADGY
YPDPEDCAMYYQCLYGFPQPFHRPCGYAGMVFNPEHLYCDWAFNVGPPCG SKA

now try doing a <a href="http://genome.jgi-psf.org/ciona4/ciona4.home.html" target="_blank">blast</a> search of the sea-squirt genome, or just click <a href="http://genome.jgi-psf.org/cgi-bin/dispGeneModel.v4?db=ciona4&id=148111" target="_blank">here</a>.

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