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Old 08-28-2002, 07:13 PM   #61
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Quote:
Originally posted by Vanderzyden:
This is not a demonstration, but merely hypothesis. I've grown weary of such assertions found in introductory biology texts, which uncritically feed undemonstrable Darwinism to unwary young people.
Hmm. The evolution conspiracy again. (Scigirl wonders if she remembered to pay her Conspiracy Dues this month.)

Vanderzyden,

Do you also feel that subjects in a biology book, such as DNA replication, or anatomy, are also "uncritically feeding undemonstratable Darwinism to unwary young people?" If not, why not?

Why pick on the evolutionists? Many theories regarding meterology, astronomy, and medicine are also difficult to demonstratably prove.

To me, it appears you are trying to mask your religious-induced disdain for evolution with an apparent concern for science. I, for one, am not fooled.

Quote:
My understanding is that translocations are not necessarily fusions, but are fragmentation of genetic components.
The way I understand it is this: A fusion can either happen with two whole chromosomes, or with one whole chromosome and a piece of another chromosome that had broken off. The latter is called a "translocation" since it used to be somewhere else. I'm not sure why you accept translocation data but disregard whole chromosome fusion data: in the former - two actions have to occur (breakage then fusion) and in the latter, just one (fusion).

In terms of your question about proof of fusions, read this site again:

<a href="http://www.gate.net/~rwms/EvoEvidence.html" target="_blank">http://www.gate.net/~rwms/EvoEvidence.html</a>

Quote:
A new centric fusion translocation in cattle: rob (13;19).

Molteni L, De Giovanni-Macchi A, Succi G, Cremonesi F, Stacchezzini S, Di Meo GP, Iannuzzi L

Institute of Animal Husbandry, Faculty of Agricultural Science, Milan, Italy.

A new Robertsonian translocation has been found in cattle. A bull from Marchigiana breed (central Italy) was found to be a heterozygous carrier of a centric fusion translocation involving cattle chromosomes 13 and 19 according to RBA-banding and cattle standard nomenclatures. CBC-banding revealed the dicentric nature of this new translocation, underlining the recent origin of this fusion. In fact, both the bull's parents and relatives had normal karyotypes. In vitro fertilization tests were also performed in the bull carrying the new translocation, in two bulls with normal karyotypes (control) and in four other bulls carrying four different translocations.
and
Quote:
J Reprod Fertil 1979 Nov;57(2):363-75

Cytogenetics and reproduction of sheep with multiple centric fusions (Robertsonian
translocations).

Bruere AN, Ellis PM

The significance of centric fusions (Robertsonian translocations) in domestic animals, with special reference to sheep, is reviewed. The mating is described of a further 856 ewes with either a normal chromosome number 2n = 54 or carrying one or more of the three different translocations (centric fusions) t1, t2 and t3 in various heterozygous and homozygous arrangements. Rams which were used in the matings were homozygous for one of the translocation chromosomes (2n = 52), double heterozygotes (2n = 52), triple heterozygotes (2n = 51) or were carriers of 4 translocation chromosomes (2n = 50) and 5 translocation chromosomes (2n = 49). A remarkably even distribution of segregation products was recorded in the progeny of all combinations of translocation ewes x translocation rams in those groups in which sufficient animals were available for statistical analysis. Forty-eight chromosomally different groups of animals were mated. Further, the overall fertility of the translocation sheep, measured by conception rate to first service, lambing percentage and number of ewes which did not breed a lamb, was not significantly different from New Zealand national sheep breeding data. In some groups the poorer reproductive performance could be explained by the age structure of the flock and inbreeding depression, which probably affected the performance of some animals. Sheep with progressively decreasing chromosome numbers, due to centric fusion, 2n = 50, 2n = 49 and 2n = 48, are reported. The 2n = 48 category represents a triple homozygous ewe and a triple homozygous ram and is the first report of the viable evolution of such domestic animals. Less than 1% of phenotypically abnormal lambs were recorded in a total of 1995 progeny born over 10 years. It is now considered that there is little or no evidence to suggest that centric fusions in a variety of combinations affect the total productive fitness of domestic sheep. It is suggested that future research should be more actively directed to understanding their genetic significance.
How's that for some cool data?


Quote:
Vanderzyden:
Perhaps scigirl or others will bring this to light when they find time to reply.
Yeah I've been busy purchasing and reading those indoctrinating books here at Denver Med School(and they are expensive I tell ya!)

Well I'm not exactly sure what more I can add to this discussion - it seems to me that despite your lack of understanding in biology, you are ready to dismiss conclusions drawn by biologists. Would you respect a critiquer of the Bible who could barely read English?

Once again, I ask - do you have any biological questions about genetics or other aspects of biology, so that you can understand the issue we are debating? I am not at all trying to be insulting, just surprised.

Thanks,

scigirl

[ August 28, 2002: Message edited by: scigirl ]</p>
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Old 08-29-2002, 03:33 AM   #62
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If you're so concerned with the children being indoctrinated, Vanderzyden, why aren't you out raising hell about all the religions - including yours - that are out there teaching kids to believe in them at such young ages...including from BIRTH? When a kid is that age you can make them believe anything...so isn't that...gasp...indoctrination?
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Old 08-29-2002, 04:13 AM   #63
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Quote:
Originally posted by Vanderzyden:
<strong>
Let me be clear: I have yet to see any convincing demonstration or argument that ANY kind of chromosome fusion occurs naturally.</strong>
Translation: “Okay, it sure as hell looks like these chromosomes fused. Now demonstrate that fusions can happen.”

Vander, call me overly simplistic, but the presence of centromeres and telomeres where predicted in these chromosomes looks to me like pretty good evidence that chromosomes can fuse. This in itself shifts the burden of proof. If I find a dagger in someone’s back, I’d need a good reason to think that something else killed him. Similarly we’d need some good reasons why chromosomes cannot fuse to discount the obvious conclusion that they have in this case. As it happens, there’s good evidence that chromosomes can and do fuse.

So tell us why they can’t.

Oolon
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Old 08-29-2002, 05:38 AM   #64
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Quote:
Originally posted by Automaton:
<strong>...I'm sure she is, but she is an actual life scientist, so her posting anything will naturally take a while due to time constraints.</strong>
Auto made some excellent points, that I and others had touched upon earlier, that the creationist now, as creationists often do, seems to be trying to weasel out of.

That is the creationist way.

It has also been clearly demonstrated that the creationist knows very little about what he writes.

That is also standard creationist fare.

To paraphrase Gould in a talk I saw him give a few years ago - if you know a little about science, creationist claims can appear to make sense. If you know a LOT about science, then it is a completely different matter.
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Old 08-29-2002, 07:06 AM   #65
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Quote:
Originally posted by scigirl:
<strong>
Hmm. The evolution conspiracy again.
</strong>
It's not a matter of active conspiracy, but NATURALISTIC DOGMATISM.

Quote:
Originally posted by scigirl:
<strong>
Why pick on the evolutionists? Many theories regarding meterology, astronomy, and medicine are also difficult to demonstratably prove.
</strong>
This is the first of several insults in your reply. Again, evolution is NOT a science. It is a collection of unsubstantiated hypotheses. (It cannot justifiably be dignified with the title theory.) Biology is a proper science, like astronomy and physics. Darwinian evolution is merely an idea.

Quote:
Originally posted by scigirl:
<strong>

Well I'm not exactly sure what more I can add to this discussion - it seems to me that despite your lack of understanding in biology, you are ready to dismiss conclusions drawn by biologists. Would you respect a critiquer of the Bible who could barely read English?

</strong>
You do realize that the default interpretation for this response is that you cannot address my inquiry. My questions aren't particularly difficult, and yet you do not even attempt to answer. I have demonstrated basic understanding of biology. Furthermore, you know nothing about me and what I know in detail. High presumption and insults are the extant characteristics of your response.


Quote:
Originally posted by scigirl:
<strong>
In terms of your question about proof of fusions, read this site again:

<a href="http://www.gate.net/~rwms/EvoEvidence.html" target="_blank">http://www.gate.net/~rwms/EvoEvidence.html</a>
</strong>
As I indicated, this site is uninformative, and contains a proliferation of faulty logic. Perhaps you should consider avoiding the citation of it any longer.

The first paper you cite apparently concerns translocations. The second discusses breeding (i.e. artificial) experiments.

Quote:
Originally posted by scigirl:
<strong>

Once again, I ask - do you have any biological questions about genetics or other aspects of biology, so that you can understand the issue we are debating? I am not at all trying to be insulting, just surprised.

Thanks,

scigirl

</strong>
I understand the issue clearly enough. What I see is that you are choosing to avoid the issue and address the challenges to your position. You don't concede that there are IMMENSE problems in positively demonstrating a mechanism, and that natural chromosome fusions are merely hypothetical.

Unless I can find--or someone can provide me--conclusive, detailed information regarding natural chromosome fusion (in any animal), then I consider this issue closed.

Vanderzyden
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Old 08-29-2002, 07:33 AM   #66
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Quote:
Why pick on the evolutionists? Many theories regarding meterology, astronomy, and medicine are also difficult to demonstratably prove.

This is the first of several insults in your reply. Again, evolution is NOT a science. It is a collection of unsubstantiated hypotheses. (It cannot justifiably be dignified with the title theory.) Biology is a proper science, like astronomy and physics. Darwinian evolution is merely an idea.
Utterly false. Darwinian evolution is one of the most thoroughly verified theories in all of science. It is supported by an overwhelming abundance of evidence.
Quote:
You do realize that the default interpretation for this response is that you cannot address my inquiry. My questions aren't particularly difficult, and yet you do not even attempt to answer. I have demonstrated basic understanding of biology. Furthermore, you know nothing about me and what I know in detail. High presumption and insults are the extant characteristics of your response.
You have asked for evidence of chromosome fusion. You have been GIVEN evidence of chromosome fusion. Stop trying to pretend that you have not been answered.

And wasn't it you who said recently that there was only one suspected transitional fossil? This speaks volumes about the state of your knowledge.
Quote:
I understand the issue clearly enough. What I see is that you are choosing to avoid the issue and address the challenges to your position. You don't concede that there are IMMENSE problems in positively demonstrating a mechanism, and that natural chromosome fusions are merely hypothetical.
Not to sane people. Any normal person can conclude from the cited evidence that chromosomal fusion has occurred. You seem to be deliberately seeking an impossible level of proof: actually watching chromosomes fuse before your very eyes. We have all the evidence that we could reasonably hope to get.
Quote:
Unless I can find--or someone can provide me--conclusive, detailed information regarding natural chromosome fusion (in any animal), then I consider this issue closed.
Let me spell out the problem you face.

The genomes of humans and chimps are virtually identical. We are more closely related to chimps than chimps are to gorillas. We are more closely related to chimps than African elephants are related to Indian elephants.

There is only ONE significant difference: we have 23 chromosome pairs and other primates have 24.

Conclusion: two chromosomes have fused. Prediction: we should be able to see the fused chromosomes.

And we can.

Even with NO OTHER EVIDENCE WHATSOEVER that chromosomes can fuse, what we have is solid evidence that fusion has occurred.

This is a true scientific prediction that has been verified. Evolution is real, rock-solid SCIENCE.

But you wish to bury your head in the sand. You are now seeking ANY EXCUSE to "close the issue", to escape from this nightmare.

Do not pretend that you have fooled us. Your motive is clear to all.
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Old 08-29-2002, 07:44 AM   #67
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This link may have already been posted, but if so maybe it'll actually get read this time.

From: <a href="http://www.grisda.org/origins/11067.htm" target="_blank">CHROMOSOMAL CHANGES IN MAMMALIAN SPECIATION</a>:

Quote:
Changes in chromosome number

Robertsonian rearrangements. A Robertsonian rearrangement (see Figure 2) is the result either of the fusion of two centromeres into one, or the fission of one centromere into two. Occasionally, a metacentric chromosome is found in one population which matches in banding pattern two acrocentric chromosomes of a different population. Matching patterns of G-banding indicate that the chromosomes are homologous (members of a pair) (see John and Freeman 1975).

The situation in which a species shows a large variation of chromosome numbers due to Robertsonian rearrangements is called a Robertsonian fan. The house mouse, Mus musculus, provides a good example. The "normal" complement of chromosomes (karyotype) consists of 40 acrocentrics. This karyotype is seen in laboratory strains of the mouse, and in wild populations from North America and many other parts of the world (see White 1978a, p. 206).


A population of house mice from the Italian Alps, which had previously been discovered to possess slight morphological differences, was discovered to have 22 chromosomes. This difference was used to confirm its specific status under the name Mus poschiavanus (Gropp, Tettenborn and Von Lehmann 1970). Many other populations have been discovered, with chromosome numbers ranging from 22 to 40 (Gropp and Winking 1981). In each case, the total number of arms is the same. Banding studies have shown that each metacentric chromosome is homologous with two acrocentric chromosomes from the "normal" karyotype (Capanna et al. 1975). It is clear that either "fusion" or "fission" is involved.

To determine whether fission or fusion is responsible for changes in chromosome number in the house mouse, it is helpful to examine the metacentric chromosomes and see which acrocentrics are involved in each. If any specific acrocentric is found only in combination with one specific partner in metacentrics from many populations, one would interpret this as evidence for the mechanism of fission. On the other hand, if any particular acrocentric may have different partners in metacentrics from many populations, one would interpret this as evidence for the mechanism of fusion. The results show that fusion has been the mechanism responsible for Robertsonian rearrangements in the house mouse, since a specific acrocentric may be found fused to a number of different partners in different populations.

Odd numbers of chromosomes are found in some individuals (Gropp and Winking 1972). This represents cases where one member of each of two pairs of acrocentrics have fused to form a metacentric, but their respective homologs have remained separate. If one of the sex chromosomes is involved, the result will be that males and females of a species will have different numbers of chromosomes. Several examples are known of species in which the number of chromosomes is different for each sex (Vorontsov 1973).
[ August 29, 2002: Message edited by: Mageth ]

[ August 29, 2002: Message edited by: Mageth ]</p>
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Old 08-29-2002, 07:54 AM   #68
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Quote:
It's not a matter of active conspiracy, but NATURALISTIC DOGMATISM.
Why don't you back this up for once instead of just throwing it out at every opportunity as if it were axiomatically true or something?

Science is, by definition, methodological naturalism, as it is the study (read: methodology) of the natural world. It cannot be anything else. If you think the success of methodological naturalism has uncomfortable ontological implications, then that's your problem, not the fault of science.

And maybe you should take up the "dogmatic naturalism" of that percentage of scientists (50% or so) that have religious beliefs.
Quote:
This is the first of several insults in your reply.
Outrageous. Where were these insults? Nothing she said was at any way directed towards you or your position, and nothing was stated in a mocking manner. She simply stated that evolution isn't the only science that is "difficult to demonstratably prove".
Quote:
Again, evolution is NOT a science.
Population geneticists, paleontologists, etc. might have to take you up on that.
Quote:
It is a collection of unsubstantiated hypotheses. (It cannot justifiably be dignified with the title theory.)
Yet you continually fail to demonstrate just why you think is "unsubstantiated". When your line of "reasoning" for this (out-of-context quotes ripped from other creationist authors) is questioned, you merely become evasive and abusive.
Quote:
Biology is a proper science, like astronomy and physics. Darwinian evolution is merely an idea.
Nothing in biology makes sense except in light of evolution.
Quote:
You do realize that the default interpretation for this response is that you cannot address my inquiry. My questions aren't particularly difficult, and yet you do not even attempt to answer.
Oh, the hypocracy! Why don't you apply this same "logic" to yourself, when you refuse to answer most of my posts? Is your default interpretation of yourself that you cannot address them?
Quote:
I have demonstrated basic understanding of biology.
*ahem* I seem to recall you stating out-right that there are no such thing as beneficial mutations.
Quote:
Furthermore, you know nothing about me and what I know in detail.
We have observed your posting, and so far, you have not demonstrated any thinking that was not spoon fed to you by another creationist.
Quote:
High presumption and insults are the extant characteristics of your response.
Stop whining and address the relevent points I and others raised. Your only (subsequential to the opening) posts on this thread have been largely rhetorical and not of any factual value (such as this one).
Quote:
As I indicated, this site is uninformative, and contains a proliferation of faulty logic. Perhaps you should consider avoiding the citation of it any longer.
Yes, you indicated, but you did not justify. Just saying something is so does not make it so.
Quote:
The first paper you cite apparently concerns translocations.
Nice attempt at obfuscation, there, but still no dice. The title of the article is "A new centric fusion translocation in cattle". It deals, specifically, unequivocally, and directly, with a fusion. Plus, there is nothing else that a chromosomal fusion could be, other than a translocation! A translocation is simply defined (in the biological sense) as a mutation where parts of the genetic code change from their original location. A fusion is a translocation, why would the latter exclude the former?
Quote:
The second discusses breeding (i.e. artificial) experiments.
This is a total evasion. It doesn't matter in which context the observation of a fusion takes place, the fact is, a centric fusion took place, out of its own means, naturally. Just because the selection was artificial, does not mean the mutation was. No act of the breeders caused the fusion.
Quote:
I understand the issue clearly enough. What I see is that you are choosing to avoid the issue and address the challenges to your position. You don't concede that there are IMMENSE problems in positively demonstrating a mechanism, and that natural chromosome fusions are merely hypothetical.
Scigirl obviously felt that what needed to be said had already been said. This is reasonable, considering you haven't even tried to respond to the criticisms given by myself, Lpetrich, and others.
Quote:
Unless I can find--or someone can provide me--conclusive, detailed information regarding natural chromosome fusion (in any animal), then I consider this issue closed.
Stop lying. Scigirl provided you with two articles demonstrating observed chromosome fusion. Your dismissals of them were simple-minded and irrelevent.
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Old 08-29-2002, 08:24 AM   #69
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Quote:
The second discusses breeding (i.e. artificial) experiments.
You acknowledged that biology is a valid science. Ecology is a valid branch of biology, a valid science. In ecology we seek to understand ecosystems but cannot directly measure ecosystem processes because spatial and temporal scales render direct measurements impractical. Therefore we develope mesocosm experiments in which we create a small, manageable artificial system that is a model of the larger system. We then extrapolate the results of the mesocosm experiments to the larger system.

A breeding experiment in which fusion occurs accomplishes the same thing for genetics that a mesocosm experiment does for ecology. It allows us to directly observe a process that was hypothesized by viewing natural systems.

[ August 29, 2002: Message edited by: scombrid ]</p>
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Old 08-29-2002, 08:48 AM   #70
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Just wondering, vander...

a) you did read my post above, yeah?

b) Are you expecting that someone has actually observed chromosomal fusion taking place? If so, don’t you think that might be a bit unreasonable? Where, when and how might someone look, eh?

So it’s obvious that observations of chromosomal fusion will either be indirect inferences, or under artificial, controlled conditions, and so not the ‘natural’ you demand. But that is no different to heaps of other science. Nobody has seen the inside of an atom or the sun, but it doesn’t stop us drawing conclusions about them indirectly from other evidence. Nevertheless...

<a href="http://www.nature.com/nsu/990318/990318-8.html" target="_blank">www.nature.com/nsu/990318/990318-8.html</a> -- ref ageing research, mice without telemerase:

Quote:
Although none of the mice showed signs of a generalized premature ageing, the sixth generation mice had a shorter life span than normal. In the later generations of mice, the fur went gray earlier and, like ageing humans, they were less able to heal skin wounds efficiently. They regenerated blood cells from bone marrow at a slower rate than do normal mice and their cells also had a higher frequency of chromosomal abnormalities resulting from chromosome fusion. The mice also showed a higher incidence of spontaneous cancer.
<a href="http://www.stowers-institute.org/labs/GolicLab.asp" target="_blank">www.stowers-institute.org/labs/GolicLab.asp</a> -- lab researching the relationship between chromosome structure and function:

Quote:
Telomeres carry out the specialized function of allowing a cell to discriminate between a natural chromosome end and chromosome damage in the form of a DNA double strand break (DSB). The variety of responses that cells exhibit to telomere loss, e.g. cell cycle arrest, cell death, and end-to-end chromosome fusion, can reasonably be thought of as the consequences of seeing a chromosome end as an irreparable DSB.

<a href="http://www.swmed.edu/home_pages/cellbio/shay-wright/publications/tin2.nature.gen.pdf" target="_blank">More ageing research (pdf)</a>:

Quote:
It seems that TRF2 maintains chromosomal stability; overexpression of mutant TRF2 in immortalized cells induces end-to-end chromosome fusion and growth arrest, as seen in replicative senescence. [ref to van Steensel, B. et al. Cell 92, 401–413 (1998)]

<a href="http://www.rockefeller.edu/labheads/delange/delangeweb.html" target="_blank">Rockerfeller University Laboratory of Cell Biology and Genetics</a>:

Quote:
We have isolated four human proteins and are studying the role of these factors in the protection and maintenance of chromosome ends. TRF1 and TRF2 are two related DNA-binding factors that coat along the length of the duplex telomeric repeat array and control telomere length. [...]

TRF2 plays an essential role in telomere protection. Inhibition of this factor leads to immediate deprotection of chromosome ends as evidenced by the loss of the telomeric 3´ tail, rapid fusion of chromosome ends and the activation of a DNA-damage response pathway. Thus, cells respond to telomeres devoid of TRF2 as if they resemble damaged DNA. An important goal is to understand the mechanism by which TRF2 protects chromosome ends.
<a href="http://link.springer.de/link/service/journals/00412/bibs/7106007/71060413.htm" target="_blank">Chromosoma Volume 106 Issue 7 (1997) pp 413-421: ‘Telomere length, chromatin structure and chromosome fusigenic potential’</a>:

Quote:
Telomeres are specialized structures at chromosome ends that are thought to function as buffers against chromosome fusion. Several studies suggest that telomere shortening may render chromosomes fusigenic. We used a novel quantitative fluorescence in situ hybridization procedure to estimate telomere length in individual mammalian chromosomes, and G-banding and chromosome painting techniques to determine chromosome fusigenic potential....
<a href="http://link.springer.de/link/service/journals/00412/contents/00/00100/" target="_blank">Chromosoma Volume 109 (2000) pp 490-497: ‘Inheritance and meiotic behaviour of a de novo chromosome fusion in the aphid Myzus persicae (Sulzer)’</a>:

Quote:
A de novo tandem fusion between autosomes 2 and 3 (A2+3), arising in the course of laboratory crosses of sexual morphs of two clones of the aphid Myzus persicae, was stable through more than 180 generations of parthenogenetic (clonal) reproduction.
Curiously, Toru M Nakamura, of the Department of Chemistry and Biochemistry at the University of Colorado, felt able to give a presentation in 1999 at the Cold Spring Harbor Meeting on Telomeres and Telomerase entitled
Prevention of chromosome fusion by telomerase in fission yeast’. But I guess yeast’s not an animal, so doesn’t count.

Sounds like without telomerase, you can’t stop the buggers fusing.

Get a pipe. I’ve got something for you to stick in it and smoke.

TTFN, Oolon

PS Ferfuckssake, I found this stuff on bloody Google. Vanderplonker, if you honestly wanted answers, why didn’t you bloody look yourself?

[ August 29, 2002: Message edited by: Oolon Colluphid ]</p>
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