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Old 01-22-2003, 06:52 PM   #71
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"By irreducibly complex I mean a single system composed of several well-matched, interacting parts that contribute to the basic function, wherein the removal of any one of the parts causes the system to effectively cease functioning. An irreducibly complex system cannot be produced directly (that is, by continuously improving the initial function, which continues to work by the same mechanism) by slight, successive modifications of a precursor system, because any precursor to an irreducibly complex system that is missing a part is by definition nonfunctional." (Michael Behe, Darwin's Black Box: The Biochemical Challenge to Evolution, 1996, p39)
DNAunion: I don't see any flaws at all in that line of logic, when properly understood, that is: it seems sound. If a system is IC, then it cannot have originated by a direct evolutionary route (consisting of a continuous, gradual series of simpler functional precursors that preformed the same function by the same mechanism).
The only problem is that you've defined "direct evolution" so narrowly that excludes basically nothing, e.g. all of these known "indirect" natural mechanisms can/have/are producing IC:

- specialization of subsystem followed by loss of part of system (Venus Flytrap lost glue from flypaper trap ancestor) -- aka scaffolding; some versions of modern photosynthesis appear to be a case of this also

- change of function (ubiquitous; PCP degradation, immune system, initial blood-clotting cascade)

- change of mechanism (mammalian inner ear bones, vertebrate camera eye, expansion of blood-clotting cascade -- in fact almost any case of specialization has now been defined to be "indirect")

Therefore *even* cases of "gradually improving the same initial function", what most people would call "direct" -- is not ruled out by IC on your strict interpretation of the Book of Behe.

Therefore IC is essentially meaningless W.R.T. inferring design. You have pretty much conceded this. Therefore there's not much point in beating the dead horse with you any further.

I will grant that you identified some cases of Ken Miller not putting all of Behe's caveats and hedges front-and-center, but then if you take all of Behe's caveats and hedges seriously then Behe hasn't really got an for design, just an argument against a ridiculously and unrealistically narrow class of "direct" evolutionary pathways. I submit that the latter was not what Behe was arguing for in his book.

You have proven this in this thread: e.g., if "missing a part" does not equate to "totally nonfunctional" but only equates to "not the same function as identified for the 'IC' system" then you have no longer got an argument against Darwinian evolution. You might find it in your heart to forgive critics for thinking that Behe was actually proposing an argument against Darwinian evolution, and interpreting his various statements, and the relative importance of his various statements, in that light.

You are aware that the idea "missing a part equates with totally nonfunctional" is by far the most common way the IC argument is put, are you not?

nic
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Old 01-22-2003, 07:08 PM   #72
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While I am still having a hard time find what Behe wrote in the last year...
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niiicholas: You are aware that the idea "missing a part equates with totally nonfunctional" is by far the most common way the IC argument is put, are you not?
Why, let's just look at some recent ARN threads.
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That some cancer cells may figure out an alternative pathway to maintain their telomeres is irrelevant as to whether telomerase can function without one of it's components. In fact, I already showed how one of these alternative pathways is also irreducibly complex. Telomere maintence itself is not an easy task:

Sitte N, Saretzki G, von Zglinicki T.
"Accelerated telomere shortening in fibroblasts after extended periods of confluency.", Free Radic Biol Med Apr;24(6):885-93 1998

There are many studies that show that breaking the function of telomerase enzyme causes cell death.

The function of telomerase and the components needed for that function are quite clear in the literature:[...]
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Normally I would be cautious when it comes to IC and "A" and "B" type systems. The reason is I would prefer to see the proteins for myself and see how they interact, etc. But from my POV, I would say yes, that this is an irreducibly complex system. You had a non-IC system, where removal of one part lead to the system simply working less specifically. A mutation occured and rendered one of those components useless without the other, so now you have a 2-part IC system.
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So you can remove say, the epsilon subunit from the F-ATP synthase and you still have ATP synthesis? In order to say something is not IC you have to reduce the function to one component of the system and that has not been done for any of the IC systems.
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Question: Nelson, how would you investigate, experimentally, whether a 2- or 3-part system is IC or not IC?
Answer: Something like this:

"A fliD-deficient mutant becomes non-motile because it lacks flagellar filaments and leaks flagellin monomer out into the medium."

Ikeda T, Oosawa K, Hotani H. 1996. Self-assembly of the filament capping protein, FliD, of bacterial flagella into an annular structure. J Mol Biol 259(4):679-86.
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Question: And how does the reassembly in the Ikeda paper demonstrate that this is IC..???
Answer: This paper shows genetic defects in organisms that lost flagellar function,

Al Mamun AA, Tominaga A, Enomoto M. 1997. Cloning and characterization of the region III flagellar operons of the four Shigella subgroups: genetic defects that cause loss of flagella of Shigella boydii and Shigella sonnei. J Bacteriol 179(14):4493-500

The only piece missing was FliD. I think the Ikeda paper shows why. This type of analysis supports IC.
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Criticism: I'm not asking for techniques, I'm asking for experiments, detailed approaches. Since you are listing IC systems, it would be nice if you can defend those. That may be difficult, so I am giving you something to "try it on", "validate", or whatever. Why come up with examples and then leave it up to critics to blow holes in them. I know, it's the traditional ID approach of not wanting to do any real work, but I was hoping for something better this time.

IC Argument: Noting that epsilon, when removed from the ATP-synthase loses function is a detailed approach, noting the function of each component of the system and what it does to contribute to the function is a detailed approach, looking at fliD deficient mutants is a detailed approach, looking at what antibiotics do to certain steps in the biosynthesis of Peptidoglycan is a detailed approach. I don't know what more you can ask for.
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Criticism: But you are not demonstrating that it is IC as meant by ID. All you do it take away parts and then it does not work anymore. That does not mean that it is IC.

IC Argument: On the contrary that is the very definition of IC, as you yourself noted for your 2-part system, or do you retract this?
http://www.arn.org/ubb/ultimatebb.ph...3;t=000576;p=2
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Secondly, when delineating IC systems, as you see me doing in the IC thread, it does indeed make use of the scientific method.

Study the basic function in a system, and the parts that contribute to that function.
-- Hypothesize which parts are absolutely essential for the system.
-- Use the hypothesis to make a prediction about the system, say if I were to look at an F-ATP synthase without the epsilon subunit, I predict that there is no atp synthesis.
-- Test the prediction by biochemical investigation and change or extend the hypothesis as needed.
-- Rinse and Repeat.
http://www.arn.org/ubb/ultimatebb.ph...3;t=000575;p=2
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Old 01-22-2003, 07:09 PM   #73
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DNAunion: I don't see any flaws at all in that line of logic, when properly understood, that is: it seems sound. If a system is IC, then it cannot have originated by a direct evolutionary route (consisting of a continuous, gradual series of simpler functional precursors that preformed the same function by the same mechanism).
Well, quite simply, thats just untrue. Have you seen this page? It demonstrates a gradual evolutionary path that starts with a simple bent wire, and finishes with a complete working mousetrap, which satisfies the IC criteria. If you have the time, invest in reading the entire article. It is the simplest refutation of the idea of IC that I have ever read.

NOTE: I do not suggest that IC does not exist. It obviously does. The question is whether gradual evolution can produce irreducibly complex systems. Intuituon says no, but demonstrations like this one prove that it can, by approaching the end product in a slightly roundabout fashion, produce such IC systems as mousetraps.
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Old 01-23-2003, 03:05 AM   #74
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Originally posted by Principia
Why, let's just look at some recent ARN threads.
Why Principia, are you suggesting that Nelson Alonzo's interpretation of Behe is vastly different than DNAunion's interpretation? That perhaps the two most dedicated Behe scholars on the web define his key concepts completely differently? How can that be, if the concept is so simple and Behe laid it out so clearly?

[/sarcasm]

I submit that perhaps there is no such thing as the "right" interpretation of things like SC and IC, because the authors (Dembski and Behe) of them were themselves inconsistent and/or vague in definition and usage.
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Old 01-23-2003, 05:45 AM   #75
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Originally posted by DNAunion
DNAunion: What, not one of the hard-core anti-Behe-ians is going to try to "refute" me on this?

I guess I should take the absolute silence from you guys as an implicit acknowledgement of the correctness of my statements. I am glad that you have all come to concede the point to me.
I deleted my last post because I did not want to be accused of 'starting' something.
The fact is, it appears that the only person concluding that you are "winning" is, not surprisingly, you.

As is most often the case.

And, of course, PZ has it right. Given your history and tendencies, why bother?
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Old 01-23-2003, 04:03 PM   #76
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DNAunion: Doubting Didymus seems to have a problem with my asking people to read material from another discussion forum. The funny thing is, I wasn’t the one to drag that other forum into the discussions here: LiveFreeOrDie did on 12/12/2002 at 01/:29 AM.

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LiveFreeOrDie: DNAunion gets his butt kicked.

www.christianforums.com/threads/29446.html
DNAunion: No comment from Doubting Didymus then? That’s odd.

And I wasn’t even the second to reference that other site: Clutch did when he responded to LiveFreeOrDie’s assertion.

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LiveFreeOrDie: DNAunion gets his butt kicked.

www.christianforums.com/threads/29446.html
*************************

Clutch: Ouch, cringe-making.
DNAunion: Again, no comment from Doubtying Didymus. Gee, I guess it’s only when I reference threads from other discussion sites that it is wrong.

Furthermore, it's not like people like Pangloss, Prinicipia, pz, etc. never drag other discussion forums into threads here.

So I guess it's the same old same old: it's not WHAT is done, but WHO is doing it.

:boohoo: (<-Saved you guys the trouble)
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Old 01-23-2003, 04:12 PM   #77
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DNAunion: FYI Nic.

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Nic: The only problem is that you've defined "direct evolution" so narrowly that excludes basically nothing, e.g. all of these known "indirect" natural mechanisms can/have/are producing IC:

- specialization of subsystem followed by loss of part of system (Venus Flytrap lost glue from flypaper trap ancestor) -- aka scaffolding; some versions of modern photosynthesis appear to be a case of this also
DNAunion: The Venus Flytrap system is not IC because it exists well above the cellular level. It’s like the Panda’s thumb that Behe addresses and says that IC/ID are quite compatible with.

Quote:
Nic: - change of mechanism (mammalian inner ear bones, vertebrate camera eye, …
DNAunion: Neither of those are IC either.
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Old 01-23-2003, 04:18 PM   #78
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DNAunion: Tell you what. One key concept can be found in posts #5 and #6, where I lay out the concept of the actual IC system being the IC core of the whole system. It is the inability of people like Ken Miller (and Lucaspa) to grasp this point that leads them astray. Does anyone disagree with my statements in just those two posts?
DNAunion: No one bothered to even address this issue, or they complained because it wasn’t posted at this site. Well, I’ll post it here, then see if anyone will address it. From that other discussion forum…



A common misconception, which seems to be the source of much confusion about Behe’s concept of irreducibly complex systems, needs to be addressed.


Behe’s IC System != Whole System
Behe’s IC System = System’s IC “Core”


One mistake many people – Ken Miller, Lucasps, and other anti-Behe’ians – make is to incorrectly assume that when Behe says a system is IC that he means all parts of the system constitute the IC system. That is incorrect: for many or most systems, some parts of the complete system are simply add-on/accessory/auxiliary parts and are not counted among the required parts that comprise the IC system itself (the IC “core”, as IDists have come to call it). And anyone who actually bothered to read Behe’s book and tried to understand Behe’s position would know this.

For example, consider what Behe states about a watch.

Quote:
Michael Behe: ”It is surprising but true that the main argument of the discredited Paley has actually never been refuted. Neither Darwin nor Dawkins, neither science nor philosophy, has explained how an irreducibly complex system such as a watch might be produced without a designer.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p213)
DNAunion: So Behe has explicitly classified a watch as being an irreducibly complex system. If we accepted what many of Behe’s detractors claim, then Behe would be saying that every single part of a watch is required for it to function. But this is clearly not what Behe holds. In fact, on page 216 he points out that Paley should not have discussed the watch cover when arguing design because a watch cover is not part of the (core) IC system itself, but merely a convenience added onto it.

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Michael Behe: “The problems start when Paley digresses from systems of necessarily interacting components to talk about arrangements that simply fit his idea of the way things ought to be. The first hint of trouble comes in Paley’s opening paragraph, when he mentions that the watch’s wheels are made of brass to prevent rust. The problem is that the exact material, brass, is not required for the watch to function. It might help, but a watch can function with wheels made of almost any hard material – probably even wood or bone. Things only get worse when Paley mentions the glass cover of the watch. Not only is the exact material not required, but the whole component is dispensable: a cover is not necessary for function of the watch. A watch cover is simply a convenience that has been attached to an irreducibly complex system itself.” (bold and contained italics added, Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p216)
DNAunion: Note that Behe – after stating that a watch is an irreducibly complex system – explicitly says that a watch cover, though surely part of the watch, is not part of the irreducibly complex system. A watch cover (or a wristband, or a nightlight) is a part that is added onto the IC watch system itself – an auxiliary part appended to the “core”. Thus, there is a “core” system within the watch that is IC, onto which accessory/auxiliary parts – such as a watch cover, or a wristband or nightlight, etc. - can be added.

This is an important point. Contrary to what we would be led to believe by Behe’s detractors, we see that the whole system (the whole watch) is not what Behe claims is IC, just a subdivision of it – the “core”. And only the subset of parts that comprise the core are the required parts: the other parts, while surely parts of the system as a whole, are not parts of the IC system itself. So removing such auxiliary/accessory parts and retaining system function does nothing to refute the concept of IC.

We can see Behe’s implicit statements of an IC core in other places in his book. For example, Behe states that swimming systems – such as the cilium and prokaryotic flagellum – are irreducibly complex. He introduces his readers to the subject by discussing a person swimming at a local pool and noting that that person’s swimming system has the same basic parts’ requirements as that of a cilium: a paddle (legs and hands/microtubules), a motor (skeletal muscles/dynein), and connectors (bones/nexin). However, he also points out that for humans, vision, though beneficial to swimming, is not part of the swimming system itself: vision is an auxiliary system that merely improves the swimming system (the former is not required for the latter to function).

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Michael Behe: ”The neighborhood pool scenario illustrates the requirements for swimming. It also shows that efficiency can be improved by adding auxiliary systems to the basic swimming equipment. … A direction-finding system (such as eyesight) is also useful for swimming; however, it is not the same thing as the ability to swim. In the story you could do the backstroke for a while and still advance through the water. Eventually, an inability to sense the surroundings can lead to accidents. Nonetheless, one can swim sighted or one can swim blind.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p56)
DNAunion: As Behe continues his introduction to swimming systems, he again notes that parts that are not required for function can be found in a system as a whole.

Quote:
Michael Behe: ”When a real-life system has more than the theoretically minimum number of parts, then you have to check each of the others parts to see if they’re required for the system to work.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p57)
DNAunion: Thus one must test to see if any “extra parts” (those other than the ones included in the theoretically minimal set of parts) are required for the system to function: if they aren’t, then they aren’t part of the IC system itself.

Even when Behe is discussing non-IC systems, he still indicates that parts that are not required for the system to function can be found in the system as a whole.

Quote:
Michael Behe: ”First, we should note that the function of the bombardier beetle’s defensive apparatus is to repel attackers. The components of the system are (1) hydrogen peroxide and hydroquinone, which are produced by the secretory lobes; (2) the enzyme catalysts, which are made by the ectodermal glands; (3) the collecting vesicle; (4) the sphincter muscle; (5) the explosion chamber; and (6) the outlet duct. Not all of these components, though, are necessary for the function of the system. Hydroquinone itself is noxious to predators. A large number of beetle species synthesize quinones that are not even secreted, but which “taste bad”. Initially a number of individual beetles are chewed up and spit out, but a predator learns to avoid their noxious counterparts in the future, and thus the species as a whole benefits from this defense.

Hydroquinone alone, then, has the defensive function that we ascribed to the entire system. Can the other components be added to the bombadier’s system in such a way that function continuously improves? It would seem that they can.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p34-35)
DNAunion: So the other 5 parts of the bombadier beetle’s defensive system are auxiliary parts – add-ons that merely enhance or improve the “core” of the system.

And again, when discussing the vertebrate eye, an integrated system of systems, Behe indicates that one should not confuse everything present as being a single system – there are accessory parts tacked on to the “core”.

Quote:
Michael Behe: ”The function of the retina alone is the perception of light. The function of the lens is to gather light and focus it. If a lens is used with a retina, the working of the retina is improved. Similarly, the muscles that focus the lens or turn the eye function as a contraction apparatus, which can be applied to many different systems. Tear ducts and eyelids are also complex systems, but separable from the function of the retina.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p38)
DNAunion: Thus, the retina would be the closest thing to the core system here, onto which the other auxiliary parts – a lens, muscles to alter the shape of the lens, etc. – are added. The auxiliary parts would not be required for the core system to perform its function.

Another system that Behe lists only a subset of parts as being the core of the IC system is the cilium. Although the answer is obvious to anyone who actually tried to understand Behe, the following question is at the heart of the controversy: when Behe says that the cilium is irreducibly complex, does he claim that the whole cilium is IC, making all parts present in a typical cilium required for function?

Absolutely not. Behe’s statement about the cilium being irreducibly complex is just like his statement that a watch is irreducibly complex. In both, what he is addressing is the IC “core” itself. Any auxiliary/accessory parts that may be present are not included as parts of the irreducibly complex system itself (the IC “core”), and removing even all of them while retaining function would not refute Behe in the least.

One might wonder, “Does Behe actually limit his statements about the cilium to just a few parts that comprise an IC ‘core’”? Yes. Behe explicitly creates a subset consisting of just three required parts that together form the IC system itself: the microtubule “paddles”, the dynein “motors”, and the nexin “linkers”. A fuller quote can be found in a previous post in this thread – this is a condensed one.

Quote:
Michael Behe: ”Now, let us sit back, review the workings of the cilium, and consider what they imply. What components are needed for a cilium to work? Ciliary motion certainly requires microtubules; otherwise, there would be no strands to slide. Additionally it requires a motor [i.e., dynein], or else the microtubules of the cilium would lie stiff and motionless. Furthermore, it requires [nexin] linkers to tug on neighboring strands, converting the sliding motion into a bending motion, and preventing the structure from falling apart. All of these are required to perform one function: ciliary motion. Just as a mousetrap does not work unless all of its constituent parts are present, ciliary motion simply does not exist in the absence of microtubules, connectors, and motors.

… All systems that move by paddling – ranging from my daughter’s toy fish to the propeller of a ship – fail if any one of the components is absent. The cilium is a member of this class of swimming systems. The microtubules are paddles, whose surface contacts the water and pushes against it. The dynein arms are the motors, supplying the force to move the system. The nexin arms are the connectors, transmitting the force of the motor from one microtubule to its neighbor.

The complexity of the cilium and other swimming systems is inherent in the task itself.” (bold added, Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p64-65)
DNAunion: The other parts of a cilium – such as the central pair, central spokes, etc. - are shown in a diagram of a cilium on page 60 of Behe’s book, but they are not listed as being parts of the IC system when Behe creates his explicit list of required parts: the central pair and central spokes aren’t parts of the IC core.

When Behe briefly returns to the cilium in a later chapter, he again lists just the three parts mentioned above.

Quote:
Michael Behe: “The function of the cilium is to be a motorized paddle. In order to achieve this function microtubules, nexin linkers, and motor proteins all have to be ordered in a precise fashion. They have to recognize each other intimately, and interact exactly. The function is not present if any of the components is missing.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p204)
DNAunion: So twice Behe restricts his list of required parts for a cilium to those three (microtubule “paddles”, dynein “motors”, and nexin “linkers”). They form the IC “core”.

Let’s go back and take another, slightly different, look at what Behe stated on page 57 of his book. Keep in mind the three required parts of the cilium Behe lists in two separate locations, as well as his saying that the cilium is a member of the class of swimming systems.

Quote:
Michael Behe: “Mechanical examples of swimming systems are easy to find. My youngest daughter has a toy wind-up fish that wiggles its tail, propelling itself somewhat awkwardly through the bathtub. The tail of the toy fish is the paddle surface, the wound spring is the energy source, and a connecting rod transmits the energy. If one of the components – the paddle, motor, or connector – is missing, then the fish goes nowhere. …

Keep in mind that we are discussing only the parts common to all swimming systems – even the most primitive. Additional complexity is frequently seen. … When a real-life system has more than the theoretically minimum number of parts, then you have to check each of the other parts to see if they’re required for the system to work.” (Michael Behe, Darwin’s Black Box: The Biochemical Challenge to Evolution, Free Press, 1996, p57)
DNAunion: Here we have two more indications that Behe does not consider the parts that Miller “removed” to be parts of the IC cilium system itself.

Already mentioned:
(1) Behe lists only three parts of the cilium as being part of the IC system itself (microtubule “paddles”, dynein “motors”, and nexin “linkers”)

Two new ones:
(2) Let’s ask ourselves, “What parts are common to all cilia, even the most ‘primitive’”?

Microtubule “paddles”? Yes.
Dynein “motors”? Yes.
Nexin “linkers”? Yes.
Central pair? No.
Central spokes? No.

So in addition to Behe’s explicitly stated subset consisting of just three parts, we have another indication that only the first three parts listed comprise the IC system itself (the “core”) with the other parts being accessory/auxiliary add-ons (and therefore, not parts of the IC system itself).

(3) Let’s ask ourselves, “What parts constitute the theoretical minimum subset of parts required for ciliary function?” Behe already answered this on pages 63-65, listing each of the three required parts and what role each one serves in completing the system function: that minimal theoretical subset consists of just the first three listed above (those with the answer, Yes). Since the central pair and central spokes are not included in the theoretically minimal set of parts required for ciliary action, one would need to test to see if they are required for the system to work. Are they required? No, there are multiple known examples of functional cilia that lack them. So are the central pair and central spokes part of the actual IC system itself? Nope. Thus, another – a third - indication that the central pair and central spokes are not to be considered parts of the IC system.

In summary, the parts of a cilium that Miller “removed” were ones that Behe never, in any way, claimed were required for ciliary function. In addition, at least three lines of evidence indicate that Behe considers those parts that Miller “removed” to not be part of the IC core (the dynein outer arms come close, but no cigar, since the dynein inner arms remained). What Miller “removed” were auxiliary/accessory parts added onto the core IC system itself. As such, Kenneth Miller’s eel-sperm-flagellum counterexample and accompanying “refutation” are to be rejected as invalid misrepresentations of Behe’s position.
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Old 01-23-2003, 04:26 PM   #79
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Originally posted by DNAunion
[B]DNAunion: Doubting Didymus seems to have a problem with my asking people to read material from another discussion forum. The funny thing is, I wasn’t the one to drag that other forum into the discussions here: LiveFreeOrDie did on 12/12/2002 at 01/:29 AM.
Are you being deliberately obtuse? Do you actually think I have a problem with links to other sites? You were requesting that infidels in THIS THREAD actually write a response to your massive tome, written on a different forum HERE. You need to read things before you respond to them. I also requested that anyone who DID want to go to the bother of responding to you should do so in the appropriate place, which is in your thread there and not this thread here. This is not an unusual request. To link to, or refer to, threads elsewhere is one thing. To drag the entire debate, half completed, to a forum where hardly anyone has been involved is an absurd proposition, that will not be happening.
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Old 01-23-2003, 04:34 PM   #80
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Again you miss the point. Irreducible complexity exists. That is not in question. The answer is that evolution CAN DEVELOP IC SYSTEMS. You and Behe can point to IC all you like, but the fact is that evolution is not troubled by it. IC evolves all the time. Case closed.
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